Repositorio Institucional de la Universidad de Burgos (RIUBU)
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An efficient gene transfer system for the pimaricin producer Streptomyces natalensis
Streptomyces natalensis produces the antifungal polyene macrolide pimaricin. Genetic manipulation of its biosynthetic genes has been hampered by the lack of efficient gene transfer systems. We have developed a gene transfer system based on intergeneric conjugation from Escherichia coli. Using this a
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