Repositorio Institucional de la Universidad de Burgos (RIUBU)
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The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis
The biosynthesis of the antifungal pimaricin in Streptomyces natalensis is very sensitive to phosphate regulation. Concentrations of inorganic phosphate above 1 mM drastically reduced pimaricin production. At 10 mM phosphate, expression of all the pimaricin biosynthesis (pim) genes including the pat
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