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Ultraconserved enhancer function does not require perfect sequence conservation

Snetkova, Valentina et al.
eScholarship · Papers
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31-biological-sciences-for-2020embryo
Ultraconserved enhancer sequences show perfect conservation between human and rodent genomes, suggesting that their functions are highly sensitive to mutation. However, current models of enhancer function do not sufficiently explain this extreme evolutionary constraint. We subjected 23 ultraconserve
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