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A fish-specific E3 ubiquitin ligase NHRE3 suppresses antiviral immunity by degrading ISG15 via ubiquitination

Juhong Xie et al.
PLOS · Papers · License: CC BY 4.0
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larvaetranscription-factorsubiquitination
Grass carp (Ctenopharyngodon Idella) hemorrhagic diseases (GCHD), caused by grass carp reovirus (GCRV), has posed a serious threat to the grass carp aquaculture industry in China. Ubiquitination plays a central role in viral evasion of the host interferon response; therefore, elucidating the mechan
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