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Oligo(uridine) tailing and exonucleolytic decay drive 40S ribosome degradation in response to stress

Diehl, F. F. et al.
bioRxiv / medRxiv · Papers · License: CC BY 4.0
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molecular-biology
Stresses like starvation trigger degradation of mature 40S ribosomes, requiring the coordinated breakdown of large and stable RNA-protein complexes. The atypical kinase RIOK3 orchestrates degradation by binding ubiquitylated 40S ribosomes and promoting rRNA decay. However, the mechanisms and factors
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