bioRxiv / medRxiv
open access
Dynamic architecture of the Rixosome reveals mechanism of activation and ITS2 processing
Eukaryotic ribosome assembly requires the coordinated processing and extensive remodeling of pre-rRNAs. During late nuclear maturation of the 60S subunit, sequential removal of the internal transcribed spacer 2 (ITS2) is initiated by endonucleolytic cleavage at site C2 by the conserved Las1 nuclease
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