HAL (France)
open access
Role of Coa6 in coordinating Cox2 and cytochrome c maturation in yeast mitochondria
Coa6 controls copper delivery into the Cox2 subunit of the mitochondrial respiratory complex IV. Mutations in COA6 lead to Cox2 degradation and cause cardiomyopathy in humans. We show that decreasing the level of the mobile electron transporter cytochrome c improves both Cox2 accumulation an
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