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Quantitative and amino acid sequence analysis of soluble HIV-1 Vpu and calmodulin interactions

Ogunbowale, A. et al.
bioRxiv / medRxiv · Papers · License: CC BY-NC-ND 4.0
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biophysics
HIV-1 Vpu supports viral adaptation through host-protein interactions. Although mainly membrane-associated, we recently identified a soluble Vpu form that forms a stable complex with Ca2+-bound calmodulin (Ca2+-CaM), potentially influencing Vpu trafficking. Here, to determine the binding affinity an
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