bioRxiv / medRxiv
open access
CC BY-NC 4.0
Motif-based model of transcription predicts effects of sequence variants in AR enhancers and reveals distinct functions for AR-associated transcription factors
Androgen receptor (AR)-mediated transcription plays a central role in prostate cancer development and progression, yet the contributions of individual transcription factors (TFs) to AR-dependent enhancer activity remain incompletely understood. Here we use a biophysically motivated, interpretable mo
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