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Connectome-Based Modeling of Mutation-Specific Amyloid-$β$ Aggregation in Familial Alzheimer's Disease
Familial amyloid-$β$ (A$β$) variants alter aggregation kinetics, but their interaction with structural brain connectivity remains incompletely understood. We developed a mutation-aware mechanistic model coupling a coarse-grained monomer--oligomer--fibril aggregation--fragmentation system to graph di
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