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Spatial and genetic dynamics of <i>Plasmodium falciparum</i> histidine-rich protein2 in sub-Saharan Africa

Kaothar O. Lambe et al.
PLOS · Papers · License: CC BY 4.0
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gene-flowphylogenetic-analysispopulation-genetics
Background: Malaria rapid diagnosis tests (mRDTs) detecting Plasmodium falciparum histidine-rich protein 2 (Pfhrp2) are the most widely adopted diagnostic tool in malaria-endemic areas. However, extensive polymorphisms in Pfhrp2 could modify Pfhrp2 epitopes, rendering it undetectable by Pfhrp2-based
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