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Uncertainty-aware integration of deuterium metabolic imaging with genome-scale metabolic modeling reveals diet-associated feasible-space remodeling in mouse skeletal muscle
Deuterium metabolic imaging (DMI) measures glucose-derived labeling in vivo, but noisy time courses complicate network-level interpretation. We developed an uncertainty-aware workflow that integrates dynamic DMI data with genome-scale metabolic modeling (GEM) through soft flux constraints. After inj
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