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Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG)

Khairkhah, N. et al.
bioRxiv / medRxiv · Papers
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Background: Diffuse midline glioma (DMG) is a lethal pediatric brain tumor driven by the H3K27M oncohistone, which disrupts epigenetic regulation and promotes tumor proliferation. While prior studies show that H3K27M is essential for tumor initiation, its role in established tumors, tumor microenvir
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