bioRxiv / medRxiv
open access
Spatially resolved gene expression and tumour-microenvironment interactions across malignant transformation in IDH-mutant glioma
Isocitrate dehydrogenase (IDH)-mutant gliomas represent most lower-grade diffuse gliomas in young adults. Although IDH-mutant gliomas initially behave indolently relative to IDH-wildtype counterparts, they undergo inevitable malignant transformation. The mechanisms driving this progression remain po
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