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From prompts to genomes: A constraint-first framework for AI-driven sequence design across life and viruses

Adhityo Wicaksono et al.
PLOS · Papers · License: CC BY
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genomics
A constraint-first framework for future ‘prompt-to-genome’ AI across Bacteria, Archaea, Eukaryota, and viruses is proposed. Genome-scale models can now generate long DNA sequences, and experimentally viable genome-scale designs have begun to appear, but sequence generation alone does not establish
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