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The Rbm38-p63 feedback loop is critical for tumor suppression and longevity
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38−/−, TAp63+/−, and Rbm38−/−;T
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