bioRxiv / medRxiv
open access
Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts
Accumulation of proteins such as amyloid beta (Abeta), hyperphosphorylated tau and alpha-synuclein within the brain alters neural information processing and causes neurodegeneration(1-3), but how toxic solutes are cleared from the brain remains highly controversial(4,5). Proposed exit routes include
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