bioRxiv / medRxiv
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Phenome-wide and proteomic analysis of APOE alleles across different ancestries in the All of Us Research Program
BackgroundApolipoprotein E (APOE) {varepsilon}4 is the strongest common genetic risk factor for Alzheimers disease and a determinant of cardiometabolic risk, yet studies of APOE genotypes with disease associations and plasma proteomic signatures have been primarily restricted to European-ancestry co
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