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Quantification of D55, an apomorphine derivative, in mouse plasma by LC–MS/MS: method development, validation, and improved pharmacokinetics compared with apomorphine
Apomorphine exhibits anti-cell death activity in mitochondrial disease models, but its short elimination half-life and dopaminergic activity limit its therapeutic application. D55 is a modified apomorphine derivative with enhanced anti-cell death activity and no dopaminergic effects. We es
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