Methods and Compositions for Reversing Endothelial-to-Mesenchymal Transition in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension, and a Cell-State Signature for Patient Stratification and Therapeutic Selection

provisional patent, patent specification, systemic sclerosis, SSc-PAH, pulmonary arterial hypertension, endothelial-to-mesenchymal transition, EndoMT, cell-state signature, patient stratification, companion diagnostic, drug repurposing, signature reversal, BMPR2, KLF2, ROCK2, belumosudil, pioglitazone, pulmonary-endothelial targeting, single-cell RNA-seq