Europe PMC
open access
<i>In vivo</i> genome editing of central nervous system SIV reservoirs in ART-suppressed rhesus macaques
Latent human immunodeficiency virus type 1 (HIV-1) reservoirs in the central nervous system (CNS) may sustain viral persistence and neuroinflammation contributing to HIV-associated neurocognitive disorders (HAND) despite suppressive ART. AAV9-delivered CRISPR has successfully edited SIV proviral DNA
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