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Innate Immunocompetent hiPSC-Derived Neurospheroids Capture Early CNS Responses to rAAV

Gomes CM et al.
Europe PMC · Papers
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central-nervous-systemgene-therapyinnate-immunity
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges because host immune responses are not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS mode
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