HAL (France)
open access
The SLC15A4–TASL complex is essential for lupus development in mice
Nucleic acid sensing by endolysosomal Toll-like receptors is critically involved in systemic lupus erythematosus (SLE) and related autoimmune diseases. Downstream of TLR7, TLR8, and TLR9, the SLE-associated SLC15A4–TASL complex selectively mediates IRF5 activation, while being dispensable for NF-κB
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