Sleep Disturbance in Patients With End-Stage Renal Disease

Sleep disorders are common in patients who have chronic kidney disease (CKD). Insomnia is reported in up to 50% of patients treated with hemodialysis compared to 12% of a control population. Restless leg syndrome (RLS) and periodic limb movement disorder (PLM) have been described in 30 to 70% of patients with end stage kidney disease (ESKD). Patients with CKD have also been reported to have a very high prevalence of sleep apnoea disorder. Conventional hemodialysis and peritoneal dialysis do not appear to improve sleep disorders in patients with CKD. There is emerging evidence that nocturnal HD can lead to improvements in sleep quality. Transplantation is thought to improve sleep-related disorders in some but not all patients. Project Aims The aims of this project were three-fold: 1. To perform detailed assessment of sleep quality in a cohort of Irish patients with ESRD 2. To assess the feasability and tolerability of unattended home PSG and wrist actigraphy as diagnostic tools in this cohort 3. To assess the impact of a change in RRT modality on sleep quality in Irish patients with ESRD