drug-repurposing

Documents about drug-repurposing

• Integrated computational and preclinical evaluation of drug repurposing candidates for KRAS-mutant non-small cell lung cancer.#457675NCBI PubMed Central
• Table 1_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197958Figshare
• Table 2_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197959Figshare
• Table 3_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197960Figshare
• Table 7_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197961Figshare
• Table 8_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197962Figshare
• Table 4_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197963Figshare
• Table 5_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197964Figshare
• Table 6_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.xlsx#197965Figshare
• Table 9_Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.docx#197966Figshare
• Integrating Drug Repurposing into EU Health Crisis Preparedness: The Strategic Role of Health Emergency Preparedness and Response Authority (HERA).#236043NCBI PubMed Central
• A Combined Chemoinformatics- and Machine Learning-Based Approach Identifies Chlormidazole as a Drug Repurposing Candidate against Aggressive Prostate Cancer.#472435NCBI PubMed Central
• The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities.#472482NCBI PubMed Central
• Drug Repurposing in Cancer and Cushing’s Disease: Halogenated Salicylanilides Inhibit USP8 Catalytic Activity and ACTH Release by Pituitary Cells#1000574HAL (France)
• Computational Identification of Repurposable Drug Candidates for Psoriatic Arthritis via Single-Cell RNA Sequencing of Synovial Tissue#174079Zenodo (CERN)
• Deciphering sepsis molecular subtypes using large-scale data to identify subtype-specific drug repurposing#145668Unpaywall
• A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG#626384PLOS
• Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19#948139Repositorio de Universidad Autónoma de Chile.
• Toward the promotion of One Health - Part II: Interdisciplinary research cooperation between digital transformation and exposome#342048Europe PMC
• Identifying potential inhibitors for wild-type EGFR tyrosine kinase through a cross-talk pathway strategy and an in-silico drug repurposing method.#305185NCBI PubMed Central
• High-throughput drug repurposing for precision medicine in the treatment of leukaemia in South African patients#990426WIReDSpace
• Screening For Potential Compounds Using Drug-Repurposing And Virtual Screening Of N-Methyl-S-Aspartate (Nmda) Receptor For Autism Spectrum Disorder (Asd)#190850USM Repository
• Modular Design of Mitochondrion-Targeted Iron Chelators Allows Highly Selective Antiparasitic Activity against Trypanosomes and Apicomplexan Parasites#274379HAL (France)
• Sapropterin as a Drug-Repurposing Candidate through the Anti-inflammatory Pathway with Microvascular Improvement in a Rat Model of Hemorrhoids#194514Indonesian Journal of Pharmacy
• Rivaroxaban suppresses factor Xa-Driven PAR-2-ERK inflammatory, catabolic, osteoclastogenic, and mitochondrial dysfunction signaling in osteoarthritis-relevant chondrocytes: a drug-repurposing strategy for joint inflammation.#923516NCBI PubMed Central
• A prototype-augmented graph representation learning framework for identifying brain disorder-associated genes and facilitating drug repurposing#240426PLOS
• Benchmarking the Impact of Data Leakage on the Performance of Knowledge Graph Embedding Models for Biomedical Link Prediction#676953HAL (France)
• Multi-Omics and network-based exploration of potential molecular pathways in heart failure relevant to left bundle branch pacing response heterogeneity: Immune remodeling, hub gene identification, and drug repurposing hypotheses.#174499NCBI PubMed Central
• Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells#248075PLOS
• Synergy Between the Auranofin Analogue PEt3AuCl and Membrane Disruptors, Efflux-Pump Blockers, and Glutathione-Depletors Uncovers Tolerance Pathways in Pseudomonas aeruginosa#326515IRIS
• Rôle de l’héparanase-1 dans les infections par le VIH-1 et le VHB : évaluation de l’inhibiteur PI-88 comme antiviral à large spectre#665309HAL (France)
• Ivarmacitinib Combined With Camrelizumab and Apatinib for Unresectable Advanced Hepatocellular Carcinoma With Acquired Resistance to Immune Checkpoint Therapy: A Single-Arm Exploratory Clinical Study#836745ClinicalTrials.gov
• Multi-Omics and network-based exploration of potential molecular pathways in heart failure relevant to left bundle branch pacing response heterogeneity: Immune remodeling, hub gene identification, and drug repurposing hypotheses#172203PLOS
• Supplementary file 1_Repurposed metformin–apigenin combination therapy for metabolic dysfunction-associated steatohepatitis: from integrative multi-omics discovery to in vivo validation.xlsx#642746Figshare
• Supplementary file 2_Repurposed metformin–apigenin combination therapy for metabolic dysfunction-associated steatohepatitis: from integrative multi-omics discovery to in vivo validation.docx#642747Figshare
• Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens#491831eScholarship
• Methods and Compositions for Reversing Endothelial-to-Mesenchymal Transition in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension, and a Cell-State Signature for Patient Stratification and Therapeutic Selection#429137Zenodo (CERN)