mendelian-randomization

Documents about mendelian-randomization

• Gut Microbiota in Constipation and Mild Cognitive Impairment: A Mendelian Randomization and Observational Study of Two Common Geriatric Syndromes.#406385NCBI PubMed Central
• The causal role of plasma protein ratios in ulcerative colitis: insights from mendelian randomization and single-cell sequencing.#446081NCBI PubMed Central
• Genetic evidence for behavioral preference factors on fatigue: A Mendelian randomization study of chronotype, morning alertness, and outdoor exposure.#446258NCBI PubMed Central
• Associations between Elevated Circulating Amino Acid Levels and Brain Health: A Mendelian Randomization Study in the UK Biobank#448661Europe PMC
• Investigating the potential causal relationship between parity and long-term maternal cardiometabolic health outcomes using Mendelian randomization#482759Europe PMC
• Global Burden of Secondhand Smoke-Attributable ER-Negative Breast Cancer and Exploratory Immune-Metabolic Mediation Using Mendelian Randomization.#636406NCBI PubMed Central
• Association of Obstructive Sleep Apnea With Risk of Myocardial Infarction: A Multivariable Mendelian Randomization and Mediation Analysis#147918Unpaywall
• Genetic predisposition to loneliness increases schizophrenia and depression risk through inflammatory pathways: a Mendelian randomization study#162290bioRxiv / medRxiv
• Single-Cell and Mendelian Randomization Analyses Identify Macrophage Polarization and Efferocytosis Biomarkers in Osteoarthritis and Reveal Their Regulatory Mechanisms.#193455NCBI PubMed Central
• Genetic and Molecular Interconnections Between Chronic Obstructive Pulmonary Disease and Osteoporosis: Insights from Single-Cell and Mendelian Randomization Analyses.#223040NCBI PubMed Central
• Causal effects of plasma protein-protein ratios on lung cancer subtypes: A proteome-wide Mendelian randomization and mediation analysis.#227852NCBI PubMed Central
• Causal role of EPA on ischemic heart disease, triglyceride rich lipoproteins and related traits: A two-sample Mendelian randomization analysis#234339bioRxiv / medRxiv
• Sleep duration may not have any effect on the risk of stroke: insights from Mendelian randomization and prospective cohort studies#250168Enlighten Publications
• Integrative analysis of GWAS, Bayesian fine-mapping, Mendelian randomization and colocalization reveals genetic determinants underlying milk-related traits in dairy cattle#250472HAL (France)
• Type 2 Diabetes Reduces IFN-α2 and Compromises Antiviral Defense: Evidence From Mendelian Randomization and H1N1-Infected Diabetic Mice.#388771NCBI PubMed Central
• Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study.#484905Europe PMC
• Immune Cell-Specific Regulatory Gene Prioritization in Low Back Pain Using Single-Cell eQTL-Informed Mendelian Randomization and Colocalization.#630948NCBI PubMed Central
• Proteome-wide Mendelian randomization implicates TIMP2 as a putative causal protein for bone mineral density and fracture risk#10162bioRxiv / medRxiv
• Triangulation of evidence to examine selection bias in lifecourse Mendelian randomization studies: an example using early life adiposity and breast cancer.#10220bioRxiv / medRxiv
• Genetic liability to endometriosis and pregnancy outcomes: a two-sample Mendelian randomization study with maternal–fetal effect decomposition#156676Unpaywall
• Identification and Validation of Mitophagy-Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single-Cell Transcriptome and Mendelian Randomization.#174514NCBI PubMed Central
• Single-cell transcriptome-wide Mendelian randomization during CD4(+) T cell activation reveals immune-mediated mechanisms and drug targets for neuropsychiatric disorders.#220912NCBI PubMed Central
• The association between asthma and ADHD in children and adolescents: An observational study and a meta-analysis of Mendelian randomization studies.#227663NCBI PubMed Central
• Explore the Causal Effect of SGLT2 Inhibition on Venous Thromboembolism Events: A Drug-Target Mendelian Randomization Study With Pharmacovigilance Analysis.#242228NCBI PubMed Central
• Global burden, projections, and causal factors of maternal sepsis and other maternal infections: A comprehensive epidemiological and mendelian randomization study.#255344NCBI PubMed Central
• Deciphering the causal influence of BMI and related metabolic, inflammatory, and cardiovascular factors on brain structure: a Mendelian Randomization Study#311515Europe PMC
• The Mechanism of Gut Microbiota in Breast Cancer Based on the Bulk Transcriptome, Mendelian Randomization Analysis and Single Cell RNA Sequencing.#3753NCBI PubMed Central
• Genetically predicted inflammatory cytokines mediate the associations between the gut microbiota and ovarian cancer: a bidirectional two-sample Mendelian randomization study.#9075NCBI PubMed Central
• Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomization#18895PLOS
• Oral Microbiota and Cardiovascular Diseases: A Study Integrating Genome-Wide Association and 16S rRNA Sequence Analyses#182049Europe PMC
• Methodological issues and recommendations in the Mendelian randomization study of cervical cancer#188797OSF
• Integrative Mendelian Randomization and Multiomics Analysis Identifies CAF-Derived Complement Factor B as a Prognostic Biomarker and Therapeutic Vulnerability in Breast Cancer.#199128NCBI PubMed Central
• Common Genetic Variation and Age of Onset of Anorexia Nervosa#257554HAL (France)
• Integrating Single-Cell Transcriptomics and Mendelian Randomization to Identify RAC1 as a Causal Metabolic Driver of Pericyte Dysfunction in Systemic Sclerosis.#285097NCBI PubMed Central
• Repurposing T‑614 for Gout: An In Silico Framework Integrating Network Pharmacology, Mendelian Randomization, and Single-Cell and Molecular Dynamics Analyses.#338555NCBI PubMed Central
• Multi-omics Mendelian randomization integrating GWAS, eQTL, mQTL and pQTL data prioritizes mitochondrial gene FXN as a hypothesis-generating candidate for nephrolithiasis.#427746NCBI PubMed Central
• Exploring the causal role and mechanism of galanin in glioblastoma: integration of mendelian randomization, network analysis, molecular docking and experimental validation.#469171NCBI PubMed Central
• IL3RA identified as novel biomarker and therapeutic target for ER(+) breast cancer through plasma proteome-wide mendelian randomization and TCGA database analysis.#9087NCBI PubMed Central
• [Key determinants of global burden of non-alcoholic fatty liver disease: machine learning combined with Mendelian randomization analysis based on GBD data].#143174NCBI PubMed Central
• Determinants of body mass index during early life: findings from an exposome-wide association study with follow-up replication and Mendelian randomization analyses#320807PubMed Central
• Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses#453123PLOS
• Investigating the Causal Relationship between Neuroticism and Alzheimer's Disease Using Mendelian Randomization and the Mediating Role of Modifiable Risk Factors#633112bioRxiv / medRxiv
• Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and mendelian randomization#127534Europe PMC
• Determinants of body mass index during early life: findings from an exposome-wide association study with follow-up replication and Mendelian randomization analyses.#312677NCBI PubMed Central
• Identifying novel modifiable risk factors for ischemic stroke through phenome-wide association study and Mendelian randomization analyses in a large-scale prospective cohort.#364786NCBI PubMed Central
• Genetically Proxied IL-6 Receptor Blockade and Cancer Risk: A Multi-Ancestry Drug-Target Mendelian Randomization Study of Hepatocellular Carcinoma and Colorectal Cancer#474700bioRxiv / medRxiv
• Natural menopause, menarche and breast cancer risk in BRCA1 and BRCA2 pathogenic variant carriers: a Mendelian randomization analysis#147712Springer Nature OA
• Exploring the relationship between gut microbiota and spinal canal stenosis: a bidirectional Mendelian randomization and hub gene study across East Asian and European populations.#340645NCBI PubMed Central
• Molecular mechanisms of suxiao jiuxin pills in ameliorating post-acute myocardial infarction inflammatory response: a combined network pharmacology, Mendelian randomization, and experimental validation study.#418344NCBI PubMed Central
• The association between frailty and headache in middle-aged and older individuals: a data analysis based on the GBD2021, the CHARLS and Mendelian randomization.#423132NCBI PubMed Central