bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
A Litmus Test for Confounding in Polygenic Scores
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on one's phenotype. However, because PGSs are constructed from population-level associations, they are influenced by fac
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