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Robust and sensitive ELISA detection of total and activated PRKN

Watzlawik JO et al.
Europe PMC · Papers
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mitochondriaparkinson-disease
Parkinson disease (PD) is closely linked to disruptions in mitochondrial quality control, a process regulated by the ubiquitin kinase PINK1 and the E3 ubiquitin ligase PRKN/parkin. Upon mitochondrial damage, PINK1 phosphorylates ubiquitin, which in turn recruits and activates PRKN. Full activation o
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